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Box 4.8

Definitions of terms

Progression: describes the development of the disease towards
worsening conditions (e.g., from “healthy” to prediabetes, to diabetes)

Regression: describes the reversal of the disease development from
having prediabetes towards normoglycaemia (e.g., from prediabetes to
“healthy”)

Remission: describes the reversal of the disease development from
diabetes to prediabetes

Diagnostic state: each diagnosable state of disease (e.g., “healthy”/
no diabetes, prediabetes, diabetes)

Table 4.9

Summary of modelling differences between the three scenarios
Base Scenario Scenario 1 Scenario 2

Progression Individuals may Individuals may Individuals may
of disease progress from being progress from being progress from being
healthy, towards healthy, towards healthy, towards
prediabetes, towards prediabetes, prediabetes, towards
DM with no towards DM with no DM with no
complications, towards complications, towards complications, towards
DM with complications DM with complications DM with complications
Progression Based on progression Based on progression Based on progression
rate of disease without of disease with of disease with
intervention intervention intervention

Remission Individuals may regress Individuals may remit Individuals may remit
towards from prediabetes to from DM towards from DM toward
health normoglycaemia prediabetes, and prediabetes, and
(healthy, without DM) subsequently regress subsequently regress
from prediabetes to from prediabetes to
normoglycaemia normoglycaemia
Mortality rates Mortality accounts for Mortality accounts for Mortality accounts for
all-cause mortality, all-cause mortality, all-cause mortality,
DM-related deaths, and DM-related deaths, and DM-related deaths, and
prediabetes-related prediabetes-related prediabetes-related
deaths deaths deaths
Mortality due to DM is
based on RAMP figures
Complications Costs determined Costs determined Costs determined
costs based on years of based on years of based on years of
DM history DM history DM history and
RAMP-adjusted costs

Additional Additional subsidy cost Additional subsidy cost
costs for management for management
services services

Additional information on the three Scenarios can be found in Appendix O.

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