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Table 10
                 Changes in percent of cost-savings in Scenario 2 due to complication
                 rates and costs of complications per patient

                                                Complication rates
                              2.0%   3.0%   4.0%   5.0%   6.0%   7.0%   8.0%   9.0%   10.0%
                   20,000    40.2%  40.0%  39.7%  39.5%   39.3%  39.0%  38.8%  38.6%  38.3%
                                                                                      32.1%
                                    38.1%
                   40,000    38.9%  36.2%  37.2%  36.4%   35.5%  34.7%  33.8%  33.0%  26.0%
               Cost per patient with one or more   complications (HKD)  80,000  36.5%  34.4%  32.3%  30.2%  28.1%  26.0%  23.9%  21.8%  19.8%
                                           34.8%
                             37.7%
                                                                               27.4%
                                                  33.3%
                                                          31.8%
                                                                 30.4%
                                                                        28.9%
                   60,000
                   100,000
                                    32.5%
                             35.2%
                                                                                      13.6%
                                                   27.1%
                                                                        19.0%
                                                          24.4%
                                                                 21.7%
                                           29.8%
                                                                               16.3%
                                                                 17.4%
                                                                                      7.4%
                                                                               10.7%
                                                                        14.0%
                                                   24.0%
                                           27.3%
                                    30.7%
                                                          20.7%
                   120,000
                             34.0%
                                                                        9.1%
                                           24.9%
                             32.8%
                                                                               5.1%
                                    28.8%
                   140,000
                                                                                      1.2%
                                                                 13.0%
                                                  20.9%
                                                          17.0%
                                                                        4.1%
                                                                                      -5.0%
                   160,000
                             30.3%
                                                                 4.4%
                                           19.9%
                                                   14.7%
                                                          9.5%
                                                                               -6.0%
                                    25.1%
                   180,000   31.5%  27.0%  22.4%   17.8%  13.3%  8.7%   -0.8%  -0.4%  -11.2%
                   200,000   29.0%  23.2%   17.4%  11.6%  5.8%   0.0%   -5.8%  -11.6%  -17.4%
            Using our projected cost-savings percentage for Scenario 2 as our base (marked brown
            borders), we then assessed combinations of rates and costs that would lead to higher cost-
            savings percentages (highlighted in green), combinations that would result in percentages
            between 27.0% and 28.0% that match our current projections (highlighted in yellow),
            combinations that would result in lower percentages (no highlights), and combinations that
            would result in net-zero or negative benefits (highlighted in red). Under our current model
            mechanics, we found that many combinations of complication rates and costs may still lead
            to higher cost-savings percentages, with costs per patients of HKD 60,000 or lower per year
            leading to higher cost-savings up to complication rates of 9.0%. Additionally, we find that the
            health system is projected to reach a net-zero cost-savings if the rate for complication
            development reaches 7.0%, with a cost per patient with complications of HKD 200,000, both
            of which far surpass the figures proposed in research. These figures are promising to the
            health system, as they suggest that the implementation of screening and management for
            diabetes is likely to be beneficial in direct budgetary terms, even when excluding indirect
            benefits to patients.
            Scenario analysis 4: RAMP-DM costs
            Within the current model mechanics, the cost of implementing the management Scheme on
            a population-wide basis is derived from the five-year cost effectiveness study of RAMP-DM,
            using an annual cost of HKD 244.92 per patient, regardless of age and level of risk (F. F. Jiao
            et al., 2018). Understandably, while this cost per patient may be reasonable when
            implemented with a smaller subset of the population with diabetes, an annual spending of
            less than HKD 300 may not be sufficient when factoring in the additional costs, for example
            due to implementation in the private sector, such as additional staffing, technology, and
            administrative costs. To assess the cost impact of a higher cost of implementation in the
            private sector, we conducted scenario analyses using annual costs of HKD 500, HKD 1,000,
            and HKD 1,500. We observe that the cost-savings in Scenario 2 decrease as the cost of
            RAMP-DM implementation increases. Nonetheless, even at a RAMP-DM implementation
            cost of HKD 1,500 per patient per year, the cost-savings percentage remains above 20%
            relative to the Base Scenario (Table 11).
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